公開中のRFP
RFP Hit-to-Lead Platform 2025-002NEW!
The GHIT Fund announces the Request for Proposals (RFP) for the Hit-to-Lead Platform (HTLP). The Hit-to-Lead Platform (HTLP) is designed to leverage Japan’s expertise in medicinal chemistry and facilitate access to relevant and diverse compounds to address the unmet needs of the following diseases.
- Malaria
- Tuberculosis
- Chagas Disease
- Schistosomiasis
- Viral Infectious Diseases with Pandemic Potential
HTLP projects will focus on the aspect of the drug discovery and development process that advances hits, identified through compound library screening, into lead compounds that can then be optimized into drug candidates. This platform will provide a bridge from early drug discovery to GHIT’s Product Development Platform that begins with the lead-optimization step.
The key requirement of the Hit-to-Lead Platform is to convert drug hits derived from Japanese compound libraries or hits identified using innovative Japanese technologies into lead series through a comprehensive assessment of chemical integrity, synthetic accessibility, scalability and novelty, functional behavior, and structure-activity relationships (SAR), as well as bio-physiochemical and absorption, distribution, metabolism and excretion (ADME) properties.
Interested applicants can find detailed information on the RFP and the Intent to Apply (ITA) form below.
The schedule is subject to change due to unforeseen circumstances.
RFP and Intent to Apply
Key RFP Milestone Dates
RFP Release June 12, 2025
Intent to Apply No later than 10:00 am JST on August 1, 2025
*Applicants are encouraged to submit the ITA well in advance of the Full proposal submission deadline shown below to secure sufficient time to prepare full proposal.
Submit via Editorial Manager® for PD&HTLP
Platform (https://www.editorialmanager.com/ghitfund/ )
Full Proposal Due No later than 10:00 am JST on September 12, 2025
Submit via Editorial Manager® for PD&HTLP
Platform (https://www.editorialmanager.com/ghitfund/ )
Full proposal templates
*Only eligible applicants will be invited to submit the full proposal and will receive instructions to access the proposal templates by email.
Proposals Evaluation and Interview Processes September 2025 - January 2026
Notification of Results January 2026
Investment Agreement Fully Executed (Awarded Proposals) March 2026