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Hit-to-Lead Platform

Past RFP

GHIT Fund RFP Hit-to-Lead Platform 2018-002

The Hit-to-Lead Platform (HTLP) is designed to leverage medicinal chemistry expertise in Japan and facilitate access to Japanese companies or academic organizations’ relevant and diverse compounds for drugs development to address malaria, tuberculosis, Chagas disease, and Visceral leishmaniasis.

 

HTLP projects will focus on the aspect of the drug discovery and development process that progresses hits, identified through compound library screening, into lead compounds that can then be optimized into drug candidates. This platform will provide a bridge from early drug discovery to our product development platform that begins with the lead-optimization step.

 

The key requirement of the Hit-to-Lead Platform is to convert drug hits originated from Japanese compound libraries into lead series through a comprehensive assessment of chemical integrity, synthetic accessibility, scalability and novelty, functional behavior, and structure-activity relationships (SAR), as well as bio-physiochemical and absorption, distribution, metabolism and excretion (ADME) properties.

 

Interested applicants can find detailed information on the RFP and the Intent to Apply (ITA) form below. An ITA should be submitted first and upon an eligibility assessment, approved applicants will be notified and request to submit a full proposal to the GHIT Fund.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

August 1, 2018

Intent to Apply

No later than 10:00 am Tokyo time on September 3, 2018
Submit Intent to Apply form to HTLPResponse@ghitfund.org
Email Subject Line: GHIT-RFP-HTLP-2018-002_Intent to Apply

Q&A

No later than 10:00 am Tokyo time on September 26, 2018
Submit questions to HTLPResponse@ghitfund.org
Email Subject Line: GHIT-RFP-HTLP-2018-002_Questions

Full Proposal Due

No later than 10:00 am Tokyo time on October 3, 2018
Submit proposal to HTLPResponse@ghitfund.org
Email Subject Line: GHIT-RFP-HTLP-2018-002_Proposal

Proposals Evaluation and Interview Processes

October 2018 - February 2019

Award Notification to All Applicants

February 2019

Investment Agreement Fully Executed (Awarded Proposals)

March 2019

GHIT Fund RFP Hit-to-Lead Platform 2018-001

The Hit-to-Lead Platform (HTLP) is designed to leverage medicinal chemistry expertise in Japan and facilitate access to Japanese companies or academic organizations’ relevant and diverse compounds for drugs development to address malaria, tuberculosis, Chagas disease, and Visceral leishmaniasis.

 

HTLP projects will focus on the aspect of the drug discovery and development process that progresses hits, identified through compound library screening, into lead compounds that can then be optimized into drug candidates. This platform will provide a bridge from early drug discovery to our product development platform that begins with the lead-optimization step.

The key requirement of the Hit-to-Lead Platform is to convert drug hits originated from Japanese compound libraries into lead series through a comprehensive assessment of chemical integrity, synthetic accessibility, scalability and novelty, functional behavior, and structure-activity relationships (SAR), as well as bio-physiochemical and absorption, distribution, metabolism and excretion (ADME) properties.

 

Interested applicants can find detailed information on the RFP and the Intent to Apply (ITA) form below. An ITA should be submitted first and upon an eligibility assessment, approved applicants will be notified and request to submit a full proposal to the GHIT Fund.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

June 8, 2018

Intent to Apply

No later than 10:00 am Tokyo time on June 15, 2018
Submit Intent to Apply form to HTLPResponse@ghitfund.org
Email Subject Line: GHIT-RFP-HTLP-2018-001_Intent to Apply

Q&A

No later than 10:00 am Tokyo time on June 22, 2018
Submit questions to HTLPResponse@ghitfund.org
Email Subject Line: GHIT-RFP-HTLP-2018-001_Questions

Full Proposal Due

No later than 10:00 am Tokyo time on June 29, 2018
Submit proposal to HTLPResponse@ghitfund.org
Email Subject Line: GHIT-RFP-HTLP-2018-001_Proposal

Proposals Evaluation and Interview Processes

July 2018

Award Notification to All Applicants

July 2018

Investment Agreement Fully Executed (Awarded Proposals)

August 2018

GHIT Fund RFP Hit-to-Lead Platform 2017-001

The Hit-to-Lead Platform (HTLP) is designed to leverage medicinal chemistry expertise in Japan and facilitate access to Japanese companies or academic organizations’ relevant and diverse compounds for drugs development to address malaria, tuberculosis, Chagas disease, and Visceral leishmaniasis.

 

HTLP projects will focus on the aspect of the drug discovery and development process that progresses hits, identified through compound library screening, into lead compounds that can then be optimized into drug candidates. This platform will provide a bridge from early drug discovery to our product development platform that begins with the lead-optimization step.

 

The key requirement of the Hit-to-Lead Platform is to convert drug hits originated from Japanese compound libraries into lead series through a comprehensive assessment of chemical integrity, synthetic accessibility, scalability and novelty, functional behavior, and structure-activity relationships (SAR), as well as bio-physiochemical and absorption, distribution, metabolism and excretion (ADME) properties.

 

Interested applicants can find detailed information on the RFP and the Intent to Apply (ITA) form below. An ITA should be submitted first and upon an eligibility assessment, approved applicants will be notified and request to submit a full proposal to the GHIT Fund.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

July 25, 2017

Intent to Apply

No later than 10:00 am Tokyo time on September 1, 2017

Submit Intent to Apply form to HTLPResponse@ghitfund.org

Email Subject Line: GHIT-RFP-HTLP-2017-001_Intent to Apply

Q&A

No later than 10:00 am Tokyo time on September 20, 2017

Submit questions to HTLPResponse@ghitfund.org

Email Subject Line: GHIT-RFP-HTLP-2017-001_Questions

Full Proposal Due

No later than 10:00 am Tokyo time on October 2, 2017

Submit proposal to HTLPResponse@ghitfund.org 

Email Subject Line: GHIT-RFP-HTLP-2017-001_Proposal

Proposals Evaluation and Interview Processes

October 2017 - January 2018

Award Notification to All Applicants

February 2018

Investment Agreement Fully Executed (Awarded Proposals)

March 2018

GHIT Fund RFP Hit-to-Lead Platform 2016-002

The Hit-to-Lead Platform (HTLP) is designed to leverage medicinal chemistry expertise in Japan and facilitate access to Japanese companies or academic organizations’ relevant and diverse compounds for drugs development to address malaria, tuberculosis, Chagas disease, and Visceral leishmaniasis.

 

HTLP projects will focus on the aspect of the drug discovery and development process that progresses hits, identified through compound library screening, into lead compounds that can then be optimized into drug candidates. This platform will provide a bridge from early drug discovery to our product development platform that begins with the lead-optimization step.

 

The key requirement of the Hit-to-Lead Platform is to convert drug hits originated from Japanese compound libraries into lead series through a comprehensive assessment of chemical integrity, synthetic accessibility, scalability and novelty, functional behavior, and structure-activity relationships (SAR), as well as bio-physiochemical and absorption, distribution, metabolism and excretion (ADME) properties.

 

Interested applicants can find detailed information on the RFP and the Intent to Apply (ITA) form below.  An ITA should be submitted first and upon an eligibility assessment, approved applicants will be notified and request to submit a full proposal to the GHIT Fund.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

August 1, 2016

Intent to Apply

No later than 10:00 am Tokyo time on September 1, 2016

 

Submit Intent to Apply form to HTLPResponse@ghitfund.org

 

Email Subject Line: GHIT-RFP-HTLP-2016-002_Intent to Apply

Q&A

No later than 10:00 am Tokyo time on September 20, 2016

 

Submit RFP questions to HTLPResponse@ghitfund.org

 

Email Subject Line: GHIT-RFP-HTLP-2016-002_Questions

Full Proposal Due

No later than 10:00 am Tokyo time on October 3, 2016

 

Submit proposal to HTLPResponse@ghitfund.org

 

Email Subject Line: GHIT-RFP-HTLP-2016-002_Proposal

Proposals Evaluation and Interview Processes

October 2016 - January 2017

Award Notification to All Applicants

No later than February 1, 2017

Investment Agreement Fully Executed (Awarded Proposals)

No later than March 31, 2017

GHIT Fund RFP Hit-to-Lead Platform 2016-001

The GHIT Fund endeavors to further facilitate collaboration & funding of global health technology R&D, to build momentum, and to demonstrate action and results. The Hit-to-Lead Platform (HTLP) is designed to leverage the Product Development Partnerships (PDPs)’ active platform for neglected and tropical diseases in partnership with Japanese companies or academic organizations that have relevant compounds. The intention is to facilitate access to the chemical diversity in Japanese research organizations and to the medicinal chemistry expertise in Japan.

 

If you are interested in applying for the platform, please see RFP.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

February 26, 2016

Intent to Apply

No later than 10:00 am Tokyo time on March 28, 2016

 

Submit Intent to Apply form to HTLPResponse@ghitfund.org

 

Email Subject Line: GHIT-RFP-HTLP-2016-001_Intent to Apply

Q&A

No later than 10:00 am Tokyo time on April 18, 2016

 

Submit questions to HTLPResponse@ghitfund.org

 

Email Subject Line: GHIT-RFP-HTLP-2016-001_Questions

Full Proposal Due

No later than 10:00 am Tokyo time on April 27, 2016

 

Submit proposal to HTLPResponse@ghitfund.org Email

 

Subject Line: GHIT-RFP-HTLP-2016-001_Proposal

Award Notification to All Applicants

No later than August 1, 2016

GHIT Fund RFP Hit-to-Lead Platform 2015-002

The GHIT Fund endeavors to further facilitate collaboration & funding of global health technology R&D, to build momentum, and to demonstrate action and results. The Hit-to-Lead Platform (HTLP) is designed to leverage the Product Development Partnerships (PDPs)’ active platform for neglected and tropical diseases in partnership with Japanese companies or academic organizations that have relevant compounds. The intention is to facilitate access to the chemical diversity in Japanese research organizations and to the medicinal chemistry expertise in Japan.

 

If you are interested in applying for the platform, please see RFP.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

August 12, 2015

Intent to Apply
No later than 10:00 am Tokyo time on October 5, 2015
 
Submit Intent to Apply form to HTLPResponse@ghitfund.org
 
Email Subject Line: GHIT-RFP-HTLP-2015-002_Intent to Apply
Q&A
No later than 10:00 am Tokyo time on November 2, 2015
 
Submit questions to  HTLPResponse@ghitfund.org
 
Email Subject Line: GHIT-RFP-HTLP-2015-002_Questions
Full Proposal Due
No later than 10:00 am Tokyo time on November 9, 2015
 
Submit questions to  HTLPResponse@ghitfund.org
 
Email Subject Line: GHIT-RFP-HTLP-2015-002_Proposal
Award Notification to All Applicants

No later than February 1, 2016

 

Investment Agreement :No later than March 1, 2016

GHIT Fund RFP Hit-to-Lead Platform 2015-001

The GHIT Fund endeavors to further facilitate collaboration & funding of global health technology R&D, to build momentum, and to demonstrate action and results. The Hit-to-Lead Platform (HTLP) is designed to leverage the Product Development Partnerships (PDPs)’ active platform for neglected and tropical diseases in partnership with Japanese companies or academic organizations that have relevant compounds. The intention is to facilitate access to the chemical diversity in Japanese research organizations and to the medicinal chemistry expertise in Japan.

 

If you are interested in applying for the platform, please see RFP.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

February 6, 2015

Intent to Apply
No later than 10:00 am Tokyo time on March 20, 2015
 
Submit Intent to Apply form to HTLPResponse@ghitfund.org
 
Email Subject Line: GHIT-RFP-HTLP-2015-001_Intent to Apply
Q&A
No later than 10:00 am Tokyo time on April 13, 2015
 
Submit questions to HTLPResponse@ghitfund.org
 
Email Subject Line: GHIT-RFP-HTLP-2015-001_Questions
Full Proposal Due
No later than 10:00 am Tokyo time on April 20, 2015
 
Submit proposal to HTLPResponse@ghitfund.org
 
Email Subject Line: GHIT-RFP-HTLP-2015-001_Proposal
Award Notification to All Applicants

No later than August 1, 2015

GHIT Fund RFP Hit-to-Lead Platform 2014-002

The GHIT Fund endeavors to further facilitate collaboration & funding of global health technology R&D, to build momentum, and to demonstrate action and results. The Hit-to-Lead Platform (HTLP) is designed to leverage the Product Development Partnerships (PDPs)’ active platform for neglected and tropical diseases in partnership with Japanese companies or academic organizations that have relevant compounds. The intention is to facilitate access to the chemical diversity in Japanese research organizations and to the medicinal chemistry expertise in Japan.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

August 6, 2014

Intent to Apply

10:00 am September 10, 2014

Submit GHIT_HTLP_RFP2014-002_Intent_To_Apply.docx to HTLPResponse@ghitfund.org

Email Subject Line: GHIT-HTLP_RFP-2014-002 Intent to Apply

Q&A

Submit Questions to HTLPResponse@ghitfund.org

Email Subject Line: GHIT-HTLP_RFP-2014-002 Questions

Full Proposal Due

10:00 am Tokyo Time October 10, 2014

Submit GHIT Fund HTLP Proposal, Timeline and Budget templates to HTLPResponse@ghitfund.org

Email Subject Line: GHIT-HTLP_RFP-2014-002 Proposal

Award Notification to All Applicants

No later than January 31, 2015

GHIT Fund RFP Hit-to-Lead Platform 2014-001

The GHIT Fund endeavors to further facilitate collaboration & funding of global health technology R&D, to build momentum, and to demonstrate action and results. The Hit-to-Lead Platform (HTLP) is designed to leverage the Product Development Partnerships (PDPs)’ active platform for neglected and tropical diseases in partnership with Japanese companies or academic organizations that have relevant compounds. The intention is to facilitate access to the chemical diversity in Japanese research organizations and to the medicinal chemistry expertise in Japan.


RFP and Intent to Apply

Key RFP Milestone Dates

RFP Release

March 17, 2014

Intent to Apply

10:00 am April 04, 2014
Submit GHIT Fund HTLP RFP2014-001 Intent To Apply to HTLPresponse@ghitfund.org
Email Subject Line: GHIT-HTLP_RFP-2014-001 Intent to Apply

Q&A

Submit Questions to HTLPresponse@ghitfund.org
Email Subject Line: GHIT-HTLP_RFP-2014-001 Questions

Full Proposal Due

10:00 am Tokyo Time April 30, 2014
Submit GHIT Fund HTLP RFP2014-001 to HTLPresponse@ghitfund.org
Email Subject Line: GHIT-HTLP_RFP-2014-001 Proposal

Award Notification to All Applicants

No later than July 15, 2014